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The second most prominent Alzheimer theory assigns a causative role to Tau, a protein that normally
helps organize and stabilize a cell’s internal "skeleton." In Alzheimer’s, Tau deforms and loses its
ability to support the cell, eventually aggregating into neurofibrillary tangles-the other hallmark
Alzheimer's brain lesion. Although no therapies targeting Tau have reached clinical trials, many experts
remain convinced that understanding Tau will reveal crucial clues about Alzheimer’s devastating effects
on nerve cells as well as chemical steps vulnerable to intervention.
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